This medication is used to treat adults and children with chronic myeloid leukemia that is Philadelphia chromosome-positive (Ph+). It also is used to treat adults and children with acute lymphoblastic leukemia that hasn’t responded to other treatments.
It is a protein-tyrosine kinase inhibitor (TKI). It blocks BCR-ABL and other proteins, which may help keep cancer cells from growing.
What is dasatinib?
Dasatinib is a medication that slows the growth of cancer cells. It is used in adults and children to treat Philadelphia chromosome-positive chronic myelogenous leukemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL).
This medicine may lower your blood counts. This can make you feel more tired and increase your risk of bleeding or bruising. Your doctor will check your blood counts often while you are taking this medicine.
Your doctor will tell you how to take this medicine and how much to take each day. You should not take any other medicines at the same time as dasatinib.
If you have a history of liver or kidney problems, talk to your doctor before taking this medicine. Also, tell your doctor if you have low levels of potassium or magnesium in your blood.
You should not take this medicine if you are pregnant or plan to become pregnant. It can cause birth defects in a developing child.
This medicine can also lower the level of red blood cells, white blood cells, and platelets in your body. This can cause swelling and shortness of breath. It can also increase your risk of getting a serious infection.
How Does dasatinib Works?
Dasatinib is a type of medication called a tyrosine kinase inhibitor (TKI). It blocks a protein called BCR-ABL on cancer cells. By blocking this protein, dasatinib can kill cancer cells and stop them from growing.
In clinical trials, dasatinib improved survival rates in people with CML who had relapsed or had stopped responding to imatinib. It also decreased the number of hematologic relapses and isolated central nervous system (CNS) relapses in these patients compared to imatinib.
Sprycel (dasatinib) is an oral medication that you take once a day with or without food. Your doctor may change your dose based on how you are responding to the medicine.
Your doctor will check your blood counts often while you are taking this medication. If your levels of red blood cells, white blood cells, or platelets are too low, your doctor will adjust your dose or stop this drug until you have the right level.
If you have a heart problem, this medication can cause abnormal heart rhythms. It can also cause anemia, which can make you feel more tired. This is especially true if you have been diagnosed with congenital long QT syndrome or are taking medications that affect your heart rhythm (e.g., amiodarone, disopyramide, quinidine, sotalol).
Dasatinib can also cause serious problems with bone growth and development in some children. In clinical studies, this happened in about 1 out of every 2,000 children.
Uses of dasatinib
Dasatinib is used to treat certain types of leukemia, including chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). It is a type of drug called a tyrosine kinase inhibitor.
It is usually given as a tablet once a day by mouth and taken with or without food. It is also given with other medicines that reduce inflammation in the body or lower the immune system. These include anti-inflammatory drugs, such as dexamethasone, and chemotherapy drugs, such as doxorubicin.
Dasatinib can be given as a treatment for patients with accelerated phase CML or Ph+ ALL who are resistant or intolerant to other therapy. It can help achieve remissions that are longer than with other treatments. Alternatively, it can be combined with less intensive treatment to prepare patients for a stem cell transplantation. For example, a phase II trial has shown that dasatinib can be used with hyper-CVAD alternating with methotrexate and cytarabine in Ph+ ALL. This regimen has been well tolerated and has led to improved remission rates in patients.
Benefits of dasatinib
Dasatinib is a cancer medicine that slows the growth of cancer cells in your body. It is used to treat people with Philadelphia chromosome-positive chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL).
This drug blocks BCR-ABL, an abnormal protein that signals cancer cells to multiply. It also blocks other proteins that help keep cancer cells from growing.
The medication can cause serious side effects, including bleeding, fluid retention (pleural effusion), and changes in heart rhythm. Talk to your doctor about these side effects and others.
Other drugs may interact with dasatinib and make it less effective or cause more side effects. Before you take dasatinib, tell your doctor about all the medications you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Blood tests will be done to monitor your dose and side effects. Your doctor will need to see your blood often during treatment and afterward.
Your doctor may give you blood thinners to lower your risk of getting a serious condition called pulmonary arterial hypertension. This condition happens when your blood pressure increases inside the arteries in your lungs, which can weaken your heart and make it harder to pump blood.
Is dasatinib chemotherapy or immunotherapy?
Dasatinib is used to treat adults and children who have Philadelphia chromosome-positive chronic myeloid leukemia (CML) or acute lymphoblastic leukemia (ALL). It works by blocking certain proteins that are responsible for the uncontrolled growth of cancer cells.
It is part of a class of drugs called protein-tyrosine kinase inhibitors. It can also be used to treat other types of cancer.
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This medication may lower your red blood cell count (anemia), white blood cell count (neutropenia), and platelet count (thrombocytopenia). You must get regular blood tests to check these numbers. Your doctor will adjust your dose or stop it if they are too low.
Your doctor will also monitor your heart and lung function while you are taking this drug. You should report any signs of fluid build-up in the arms, legs, heart, or lungs such as shortness of breath, dry cough, swelling of the legs or ankles, weight gain, and fatigue.
The drug can also lower your blood cell counts and make it harder for your body to fight infection. Report any unusual bruising or bleeding, or symptoms of infection such as fever, chills, or body aches to your doctor immediately.
Precautions
- Avoid taking other drugs that have a similar effect on your body as dasatinib while you are on this medication. They can increase your chance of toxicity, or make it harder for you to absorb dasatinib.
- If you have any questions about this medication, talk to your doctor or pharmacist. They can answer your questions and give you important information.
- In addition, this medicine can harm your baby if you are pregnant. It can also affect your baby’s growth and development if you are breastfeeding.
- Tell your doctor if you have any symptoms of a reaction to dasatinib, such as hives, difficulty breathing, swelling in your face or throat, skin rash, or itching.
